First words in space...

On 12 April, 1961, 06:17 UTC Yuri Gagarin, from Vostok 1 spacecraft, said "The craft is operating normally. I can see Earth in the view port of the Vzor. Everything is proceeding as planned".

Perhaps not the most inspiring words, but nonetheless, the first words a man has spoken outside Earth.

Good enough for me. You can read the entire transcript from the mission here.